ABSTRACT
Background: The mandibular foramen, is the emerging point of the neurovascular bundle which makes it fundamental for performing anaesthetic techniques for desensitization of the mandible in oral surgery interventions. The knowledge of position of mandibular foramen is neccessary while anaesthetizing palate during periodontal procedures, tooth extractions and maxillofacial surgeries. Objective: The present study was carried out to identify the position and location of mandibular foramen in relation to the angle of mandible (gonial angle) in adult human mandibles of Indian origin . Materials and Methods: The study was conducted on 300 adult human dry skulls of Indian Population. Angle of mandible, Distance of mandibular foramen from angle of mandible and Angle of mandibular foramen with the base of mandible were measured. Measurements were done with Steel measuring tape and Mylometer. The data was Statistically analysed. Results and Conclusion: The Mean value of the angle of mandible (Gonial Angle) was 121.870 ± 6.220. The Mean value of the distance of mandibular foramen from angle of mandible was 22.78± 4.05 mm. The angle of mandibular foramen was Mean ± standard deviation of 82.240± 6.870. The morphometric correlation of the parameters analyzed in the mandibles showed a statistically significant Pearson correlation. Regression line was also derived.
ABSTRACT
Solid dispersion of Rosuvastatin was prepared by solvent evaporation method; PEG (Polyethylene glycol) 4000, mannitol and urea were used as carriers. Hydrotropic studies were carried out using different hydrotropic agents (sodium acetate, sodium benzoate and salicylate) and Micellar solubilization was carried out using different surfactant solutions (sodium lauryl sulphate, tween 80 and cetrimide).The solubility enhancement of Rosuvastatin by different solubilization technique was observed in decreasing order as hydrotropic solubilization > solid dispersion > micellar solubilization. It was observed that the solubility increased with the increase in the concentration of hydrotropic agents and amongst the various hydrotropic agents used the solubility was Rosuvastatin was enhanced greatest to 55 folds with sodium salicylate. This increase may be attributed due to aggregation of the hydrotropic molecules and inclusion of one of these aggregates at high concentration probably by reacting to form an associated product as a result of hydrogen bonding.